Micellar electrokinetic chromatography (MEKC) is a separation mode of capillary electrophoresis (CE). Its separation principle is based on the differential migration of the ionic micelles (surfactant molecules) and surrounding aqueous buffer solution under electrophoresis conditions and on the interaction between the analyte and the micelle. Unlike conventional CE, the solution contains a surfactant at a concentration that is greater than the critical micelle concentration MEKC is a useful technique for the separation of small molecules.
